Further, when the NOD-SCID mice with intrasplenic implantation of DMBT1-overexpressing MCF7 cancer cells were treated by daily intraperitoneal injection of GO203, GO203 blocked the induction of CD62L+ KCs (Fig. 7h), reduced cancer cell colonization (Fig. 7i–k) and suppressed NET formation in the liver (Fig. 7l), although GO203 displayed considerable toxicity with significant body weight loss in treated animals (Fig. 7m). The gene discussed is TBCE; the disease is cancer.