Using RNA-seq data from CD4+ T cells isolated from 66 ATLL patients and 3 healthy controls (Kataoka et al, 2015; Kogure et al, 2022), we found that both alpha-SMA (ACTA2) and ICAM-1 (ICAM1) were significantly upregulated in ATLL samples, whereas expression of gamma-actin (ACTG1), CD18 (ITGB2), and the housekeeping gene beta-glucuronidase (GUSB) remained unchanged (Fig. 8D). This evidence concerns the gene ACTA2 and adult T-cell leukemia/lymphoma.