LRRK2 and Parkinson disease: To directly investigate the crosstalk between extracellular NM and microglial activation in the context of pathogenic LRRK2 mutations, we generated iPSC-derived microglia (hMG) from two PD patients carrying the LRRK2 G2019S mutation (L2-PD) along with their respective isogenic controls (L2-PDcorr) and healthy individuals (CTL).