Because the mechanisms by which ubiquitination modifications affect specific gene expression are interrelated, the present study not only reveals important protein degradation mechanisms for HK2 inhibition and glycolysis but also suggests that the anti-gastric cancer effects of HK2 inhibition and metabolic heterogeneity can be achieved through NLRP12 and other possible molecular interventions. The gene discussed is NLRP12; the disease is gastric cancer.