Previous studies have shown that H3K18la-mediated VCAM1 expression promotes gastric cancer progression and metastasis via the AKT‒mTOR‒CXCL1 axis [10]; lactic acid accumulation resulting in H3K18la promotes PD-L1 transcription, thereby mediating the immune escape of gastric cancer cells [11]. This evidence concerns the gene CD274 and gastric cancer.