Our experiments demonstrated that YAP+Sox9+ LPCs may be a source of JAG1+ exosomes and that YAP-induced hepatocytes can release JAG1+ exosomes via the SEC31A/ALG-2/Alix axis, thereby activating the Notch signaling pathway in neighboring cells to promote liver regeneration in PVL rats. This evidence concerns the gene ALG2 and periventricular leukomalacia.