Ten well-documented breast cancer marker genes were selected [PIP (Urbaniak et al. 2018), SHISA2 (Cheishvili et al. 2015), PDZK1IP1 (Garcia-Heredia et al. 2017), PLEKHS1 (Weinhold et al. 2014), NAT1 (Johansson et al. 2012), TFAP2C (Woodfield et al. 2007), NPNT (Wang et al. 2018a), SCUBE2 (Chen et al. 2018), ASCL2 (Xu et al. 2017), DNAJC1 (Zoppino et al. 2018)], whose expression is expected to correlate strongly with the presence of cancer epithelial cells. This evidence concerns the gene SCUBE2 and cancer.