MKI67 and neoplasm: Importantly, Haralick entropy also achieved higher C-index values (0.709 [95% CI, 0.668-0.757] for HALO; 0.701 [95% CI, 0.655-0.748] for Aiforia) compared to visual Ki67% (0.672; 95% CI, 0.623-0.726) and DIA-derived Ki67% (0.687-0.688; 95% CI, 0.635-0.738), underscoring the potential added value of metrics that capture both local proportion of proliferating tumor cells and regional variance of the latter.