LEP and congenital adrenal hyperplasia: The published evidence is sparse and not fully conclusive, with some studies describing either altered or normal leptin concentrations22,23 and others reporting high adiponectin concentrations in children with 21OHD.24 In this study, we aimed to explore the relationship of adipokines with body weight, GC treatment and the hormonal biomarkers, as a first step towards gaining more insight into the mechanisms involved in the development of metabolic disease in CAH.