Moreover, GCs interfere directly with the insulin signalling pathway by directly inhibiting components such as glycogen synthase kinase-3, glycogen synthase, glucose transporter type 4 translocation, further inhibiting insulin-mediated glucose uptake.10 GCs induce the activity of lipoprotein lipase, thus increasing the release of fatty acids into the bloodstream, which interferes with glucose utilization and results in insulin resistance.7 They promote the differentiation of adipocytes and increase the uptake and turnover of fatty acids in the adipose tissue. Here, INS is linked to Insulin resistance.