Consistent with previous studies in diet-induced obesity in mice,3,4,44,45 our cohorts of HFD mice exhibited leukocytosis and monocytosis (CD115+Ly6G−Ly6C+) in the blood and increased abundance of myeloid compartments such as GMP cells (Lin−Sca1−cKit+FcγR+CD34+) in the BM but showed unaltered LSK HSPCs (Fig. 1A). Here, CD34 is linked to obesity due to melanocortin 4 receptor deficiency.