In contrast to mouse models of EOAD, mice carrying the K257T/P301S double mutation in the human Tau gene (associated with frontotemporal dementia and tauopathy but lacking the expression of human Aβ plaques) revealed remarkably low numbers of meningeal ELS in >18-mo-old females compared with WT mice (5.40 ± 2.18 and 14.25 ± 3.43, respectively; SI Appendix, Fig. S6A). The gene discussed is MAPT; the disease is frontotemporal dementia.