GDPGP1 and hyperinsulinemic hypoglycemia, familial, 4: Moreover, only 11 out of the 119 up-regulated genes in vtc2-4 overlapped with the 378 up-regulated genes in the vtc2 dataset from Kerchev et al. (2011) (Supplementary Table S2), suggesting the condition-specific nature of transcriptomic responses to ascorbate deficiency.