While we did not study the effect of CERT depletion on inclusion stability in this study, our findings indicated that CERT depletion also sensitizes cells mildly to CTL2-induced cytotoxicity (S6 Fig and S8 Data), possibly also reflecting a certain degree of inclusion destabilization to occur under these conditions at later infection stages and thus indicating a minor role of the CERT-mediated ceramide transport route in supplying lipids for inclusion stability. The gene discussed is CERT1; the disease is infection.