Moreover, despite being cytoprotective, CERT depletion did not significantly increase the number of inclusions detectable after infection with CTL2-cpoS::cat and many cells in cultures infected with this strain were inclusion-free, suggesting that CERT depletion, similar to SPTLC1 depletion and KDSR deficiency, may have a growth-suppressing rather than a growth-restoring effect on CTL2-cpoS::cat (S6E–S6F Fig and S8H Data). Here, SPTLC1 is linked to infection.