Wang et al. (2020)the infertile man with PLCZ1 mutation was treated with intracytoplasmic sperm injection (ICSI identified a homozygous PLCZ1 nonsense mutation c.588C > A (p.Cys196Ter), which had a low fertilization rate and poor embryo development after ICSI + AOA treatment. The gene discussed is PLCZ1; the disease is Infertility.