Positive correlations were found between the LH:FSH ratio and LBR and CLBR, opposite to what Singh et al., and other authors describe: a high LH:FSH ratio does not impair the outcome of IVF/ICSI cycles in women with PCOS (Ganor-Paz et al., 2016; Singh et al., 2021). The gene discussed is BRD2; the disease is polycystic ovary syndrome.