In both genotypes (WT and KO) and treatment groups (Veh and Bc), CD163+ Toe-Macs were detected within tumor regions (Figure 7H) expressing high levels of NLRP3 (Figure 7I), IL-1β (Supplemental Figure 15A), TGF-β1 (Supplemental Figure 15B), CCL2 (Supplemental Figure 15C), IL-6 (Supplemental Figure 15D), and PD-L1 (Supplemental Figure 15E). The gene discussed is CCL2; the disease is neoplasm.