To determine if differences between signaling downstream of TLR779 and TLR777 affect disease severity in vivo, we assessed lupus-associated phenotypes in Tlr7+/+ Tlr9–/–, Tlr779/779 Tlr9–/– MRL/lpr mice (Figure 3A). The gene discussed is TLR7; the disease is systemic lupus erythematosus.