It has been revealed that PON2 amplification in multiple cancer cell lines lowers endoplasmic reticulum stress-induced apoptosis and mitochondrial superoxide generation (Witte et al. 2011), whereas it has been found that miR-376a-3p targets and downregulates PON2 by inflicting post-transcriptional suppression in thyroid cancer cells (Xie et al. 2021). Here, PON2 is linked to thyroid gland carcinoma.