PRRT2 and Hyperglycemia: D-saccharic acid 1–4-lactone can inhibit liver injury caused by hyperglycemia (Bhattacharya et al. 2013a, b), moreover, it ameliorates hyperglycemia-induced oxidative stress and inflammation via modulation of Nf-κB and PKC signaling pathways, thereby exerting protective effects against metabolic dysfunction (Bhattacharya et al. 2013, Bhattacharya et al. 2013).