Similarities between the DNA methylation and gene expression profiles between extracranial MRT and tumours of the AT/RT-MYC subgroup are suggestive of common dysregulated developmental programs and that they arise from a neural crest-derived lineage shared with Schwann cells and blocked on their way to mesenchymal differentiation [175, 178, 179, 304, 315]. Here, MYC is linked to neoplasm.