JUN and melanoma: AT/RT subgroups) has been shown to lead to the specific loss of expression of the AP-1 subunit c-JUN, which normally organises the expression of lineage-specific transcription factors [294]. Importantly, in melanoma cellular models, loss of c-JUN or other members of the AP-1 transcription factor network is associated with a poorly differentiated state [295]. Thus, the cooperativity between the BAF complex and lineage-specific transcription factors indicates that both are important regulators of cellular identity [294].