SMARCB1 and neoplasm: The different pathologies associated with germline SMARCB1 PVs are likely to be caused by a number of different determinants including the type of pathogenic SMARCB1 variant and its position within the different regions/domains of the gene/protein, the timing of the loss of the second SMARCB1 allele, the type of mutation associated with the loss of the second SMARCB1 allele (intragenic PV, large deletion, loss of chromosome 22q), the cellular origin of the tumour progenitor cells and the possible concomitant loss of other tumour suppressor genes.