To evaluate the effect of NCOA4 on the growth of glioma cells, Adv-NCOA4 was used to overexpress NCOA4 in U251 and TJ905 cells, and siRNA-NCOA4 was used to knockdown NCOA4 in 23N and U87 cells (Fig. 3A). The gene discussed is NCOA4; the disease is central nervous system cancer.