In addition, the positive correlations seen with platelet count also align with the multifactorial causes of thrombocytopenia in chronic liver disease, including decreased platelet production [39], hypersplenism related to portal hypertension [40] and increased platelet destruction due to decreased levels of A disintegrin-like and “metalloprotease with thrombospondin type 1 motif 13” (ADAMTS13) [41] and immunologically mediated destruction [42]. This evidence concerns the gene ADAMTS13 and hypersplenism.