The receptor activator of nuclear factor kappa-B ligand (RANKL) was reported to be increased in the serum and the liver of mice with HFD-induced NAFLD, thus promoting the hepatic infiltration of macrophages as a downstream effector of Runt-related transcription factor 2 (Runx2) [45]. The gene discussed is RUNX2; the disease is metabolic dysfunction-associated steatotic liver disease.