IL6 and obesity due to melanocortin 4 receptor deficiency: Mice knockout for IL-6 (il6−/−) on HFD developed obesity, NASH, and IR [182], and mice with hepatocyte-specific deficiency of IL-6Rα developed IR not only in the liver, but also in the skeletal muscle and adipose tissue, associated with exacerbated hepatic inflammation [183]; the latter is indicative of cross-talk between the liver and the skeletal muscle and adipose tissue.