TNF-related apoptosis-inducing ligand (TRAIL), also known as TNF ligand superfamily member 10 (TNFSF10), is a peptide that induces apoptosis upon binding to the death receptors (DR)4 and DR5, which are upregulated in murine and human NASH [29, 30]. This evidence concerns the gene TNFSF10 and metabolic dysfunction-associated steatohepatitis.