This finding aligns with some earlier observations in NAFLD mice fed a HFD, in which knockout of IL-1 receptor 1 (IL-1R1) in the hepatocytes (IL1R1Hep−/−) resulted in reduced hepatic steatosis, alanine aminotransferase (ALT), and IR compared to WT mice [58]; on the contrary, IL-1β inhibition did not ameliorate NASH in a choline-deficient L-amino-defined (CDAA) mouse model of NASH in another study [59]. Here, IL1R1 is linked to metabolic dysfunction-associated steatotic liver disease.