However, based on the existing evidence, we hardly could propose the use of a single cytokine or a combination of cytokines for the non-invasive diagnosis of MASLD, although some of them have been incorporated into predictive models of either MASH (TNF-α, FasL [42], CXCL8 [149]) or hepatic fibrosis (IL-34 [75]) together with other variables. Here, CXCL8 is linked to metabolic dysfunction-associated steatotic liver disease.