Interestingly, recent insights have highlighted a “domino effect” in MASLD, according to which chronic hepatocyte stress is initially detected by tissue-resident immune cells that reside in the space of Disse next to hepatocytes and endothelium (γδ T cells, dendritic cells, and CD4 − CD8 − double-negative T cells), which are the first line of defense [15]. Here, CD8A is linked to metabolic dysfunction-associated steatotic liver disease.