IL2RA and Hepatic fibrosis: On the contrary, IL-2Rα, which is a soluble receptor of IL-2 and is regarded as a marker of T-cell activation (as it is expressed and secreted by activated T lymphocytes, but not by quiescent T lymphocytes, which express only IL-2Rβ and IL-2Rγ on their surface), was associated with the severity of NAFLD; specifically higher circulating IL-2Rα levels were associated with significant hepatic fibrosis in histologically confirmed adult and pediatric patients with NAFLD [92, 143].