In line, hepatic expression of LIGHT, HVEM, and LTβR was increased in mice fed a high-fat high-cholesterol diet (HFHCD) compared to WT mice, whereas LIGHT deficiency (light−/−) in mice on HFHCD resulted in lower IR and hepatic steatosis and reduced hepatic, adipose tissue, and systemic inflammation compared to WT mice under the same diet (HFHCD) [53]. The gene discussed is TNFSF14; the disease is fatty liver disease.