IL10 and metabolic dysfunction-associated steatotic liver disease: Of note, although a meta-analysis did not show a significant association between circulating IL-10 and human NAFLD [27] (based only in one study with pediatric population [92]), an observational study that was not included in this meta-analysis reported that hepatic and circulating IL-10 decreased in obese patients with moderate or severe hepatic lobular inflammation compared to those with mild hepatic lobular inflammation; this seems to be rational because an unfavorable Tregs balance is expected in NAFLD [93].