In addition, the single nucleotide polymorphism (SNP) rs4788084 in the promoter of the IL-27 gene was associated with higher hepatic fat content and probably with a higher risk of NASH development among Indians [99], a finding implying that this SNP may lead to diminished or dysfunctional IL-27, but its clinical implication requires further research. Here, IL27 is linked to metabolic dysfunction-associated steatohepatitis.