Similar correlations were discovered in rectal adenocarcinoma, where CTSS expression was positively correlated with regulatory T-cells (Rho = 0.341, P = 1.01 × 10−3) and M2 macrophages (Rho = 0.314, P = 2.62 × 10−3; Supplementary Fig. 2C and D). The gene discussed is CTSS; the disease is rectum adenocarcinoma.