Previous studies have indicated that CRTC1 transcription domain is linked with extending the lifespan in C. elegans (Silva-García et al., 2023) and a decrease in CRTC1 levels was found to be associated with human Alzheimer’s disease (AD) (Mendioroz et al., 2016). The gene discussed is CRTC1; the disease is early-onset autosomal dominant Alzheimer disease.