Increasing PSA (OR=4.59, p<0.001), ALP (OR=4.24, p<0.001), DRE risk group (OR=1.60, p<0.05), and International Society of Urological Pathology (ISUP) (OR=1.72, p<0.05) were associated with increasing risk of bone metastasis. The gene discussed is KLK3; the disease is bone metastasis.