ALP, alkaline phosphatase; PSA, prostate-specific antigen; ISUP, International Society of Urological Pathology grade group; DRE_Risk, clinical risk level based on digital rectal examination findings; %HistVol/volHist, the percentage volume of the tumor biopsy cores with adenocarcinoma involvement; PeriInv, perineural invasion; Cat, category; AUC, area under the ROC curve; ROC, receiver operating characteristic curve; TN, true negatives; FP, false positives; FN, false negatives; TP, true positives. The gene discussed is KLK3; the disease is adenocarcinoma.