KLK3 and prostate cancer: H6: Combining serum PSA, ALP, DRE, ISUP, bone pain, a histology of cribriform pattern, perineural/perivascular invasion, and the percentage core involvement of adenocarcinoma (eight-parameter model) yields a statically significant improvement in determining bone metastasis in prostate cancer than the combined serum PSA, ALP, ISUP, and DRE (four-parameter model).