KLK3 and bone metastasis: As shown by the calculated intra-row percentages in Table 4 for "bone metastasis," as predicted by the stated categories of the independent parameters (PSA, DRE, ISUP, D-Amico, bone pain, cribriform pattern, perineural invasion, percentage core involvement, and ALP), as the categories increase in value, the yield for bone metastasis also increases: for serum PSA, 0% for the 0 to 4 ng/mL group to 93% for the >500 ng/mL group.