MUC16 and ovarian carcinoma: The clinical characteristics of the EOC cohort are detailed in Supplementary Table S3: within the 15 patients with EOC, 12 patients (80.0%) presented with symptoms at the time of diagnosis, including abdominal pain, abdominal distension, loss of appetite and vaginal bleeding, and 14 (93.3%) patients had CA125 ≥35U/ml, 6 (40.0%) patients had early stage (FIGO stages I and II) epithelial ovarian cancer, 4 (26.7%) patients showed lymph node involvement and 7 (46.7%) patients presented with peritoneal metastases.