This case describes a 57-year-old man with simultaneous diagnoses of resectable stage IIIA NSCLC and <i>PDGFRA</i>-rearranged myeloid neoplasm who received neoadjuvant chemotherapy and nivolumab in combination with imatinib prior to definitive resection. This evidence concerns the gene PDGFRA and non-small cell lung carcinoma.