To illustrate, IFN-induced activation of signal transducer and activator of transcription 1, a vital response to viral infection that is increased in natural killer cells, monocytes and myeloid dendritic cells (DCs) during gestation.45 The innate antiviral response to DENV is regulated by a variety of immune cells and inflammatory mediators. The gene discussed is IFNA1; the disease is viral infectious disease.