However, due to hemodynamic changes or increased degradation and clearance rates of natriuretic peptide, the effects of ANP are attenuated, resulting in reduced ability to inhibit RAAS, while also causing dysregulation of the cGMP/PKG signaling pathway, which contribute to the development of HF (Abassi et al., 2022). This evidence concerns the gene PRKG1 and hydrops fetalis.