Similarly, neutralization of SAP130 or blockage of the Mincle/syk pathway by BAY61-3606 attenuated neuroinflammation and neurological deficits in the traumatic brain injury animal model, highlighting the contribution of Mincle in the pathology of traumatic brain injury (He et al., 2022; de Rivero Vaccari et al., 2015). This evidence concerns the gene CLEC4E and brain injury.