In the central nervous system, it has been found that the SAP130/Mincle axis is involved in promoting neuroinflammation in various brain injury rodent models, including ischemic stroke, traumatic brain injury, and subarachnoid hemorrhage (de Rivero Vaccari et al., 2015; He et al., 2015; Suzuki et al., 2013). Here, SAP130 is linked to subarachnoid hemorrhage.