In the central nervous system, it has been found that the SAP130/Mincle axis is involved in promoting neuroinflammation in various brain injury rodent models, including ischemic stroke, traumatic brain injury, and subarachnoid hemorrhage (de Rivero Vaccari et al., 2015; He et al., 2015; Suzuki et al., 2013). The gene discussed is CLEC4E; the disease is ischemic stroke.