This sheds light on the intricate hypermethylation profile of HOXA10 gene, negatively regulating HOXA10 expression and contributing to the heterogeneity of endometriosis (Table 1) (Ji et al., 2017; Samadieh et al., 2019; Elias et al., 2023; Ekanayake et al., 2022). This evidence concerns the gene HOXA10 and endometriosis.