,12,18 These mechanisms of disruption are established, but they contrast with the PIEZO1 gain-of-function mechanism of dehydrated hereditary stomatocytosis (DHS) in which adverse effects on red blood cells arise from changes in PIEZO1 channel activity such as the slowing of the channel’s inactivation, which reduces the desensitization of the channels in response to sustained force.21 The gene discussed is PIEZO1; the disease is hereditary stomatocytosis.