Laboratory investigations revealed significantly elevated levels of B-type natriuretic peptide (BNP) in 96.7% of patients (95.0% of CHF patients, 99.1% of ACHF patients, and 98.8% of DNHF patients) and N-terminal proBNP (NT-proBNP) in 90.9% of patients (88.6% of CHF patients, 92.7% of ACHF patients, and 97.8% of DNHF patients). This evidence concerns the gene NPPB and congestive heart failure.