Here, we utilize patient derived GS and multiple sources of transcriptomic data to identify genetic modifiers of the disease phenotype in cardiomyopathy patients with a previously identified variant in MYH7. We develop a pipeline specific to cardiomyopathy, update curation of all putatively causal variants, and examine several aspects of variation uniquely available in genome data. This evidence concerns the gene MYH7 and cardiomyopathy.