In this work, we have effectively applied integrative machine learning and bioinformatics approaches to identify key cellular senescence-related genes, namely, ABCB1, CXCL1, TACC3, TGFβI, and VDR, that show promising potential as diagnostic biomarkers and therapeutic targets in the progression from ulcerative colitis to colorectal cancer. Here, ABCB1 is linked to ulcerative colitis.