ABCB1 helps protect cells from toxic compounds but also contributes to multidrug resistance (MDR) in colorectal cancer cells by reducing the intracellular concentration of anticancer drugs, including doxorubicin, paclitaxel, and vincristine, making them less effective (Tan et al., 2022; Lei et al., 2024). Here, ABCB1 is linked to colorectal cancer.