Furthermore, western blot analysis revealed that Fe(III)-COF and SRF@Fe(III)-COF effectively downregulated GPX4 in H22 cells and human HCC cell lines (HepG2 and Huh-7) (Fig. 4E and F; Fig. S11), confirming its ability to induce ferroptosis in HCC cells. Here, GPX4 is linked to hepatocellular carcinoma.