Tajalli-Nezhad et al. found that a single dose of calcitriol administered 24 h after a stroke significantly reduces the expression of TLR4/2 and NF-κB, which leads to decreasing the levels of inflammatory factors in the ischemic stroke patients (Tajalli-Nezhad et al., 2023). This evidence concerns the gene NFKB1 and ischemic stroke.