HDGFL2 and infection: 2 However, mRDTs face limitations, including inadequate sensitivity leading to false negatives, false positives due to lingering histidine rich protein 2 (HRP2) antigen after treatment, and reduced sensitivity to non-falciparum infections.2,3 Additionally, Pfhrp2 and Pfhrp3 gene deletions in P. falciparum have raised concerns about HRP2/3-based mRDT accuracy, as these deletions can result in undetected infections.