NOD2 and inflammatory bowel disease: Notably, four of the six of the known variants in NOD2 that were detected in our cohort were significantly enriched in French Canadians (1.5- to 2.4-fold enrichment in the FC controls subset relative to gnomAD NFEs, one-sided Fisher exact test p-value < 0.05), and five had significant association to CD/IBD and conferred increased risk.