This study aimed to investigate changes in BDNF expression associated with CKD using a multidimensional approach, including (Francis et al., 2024) a meta-analysis of studies to assess serum BDNF reduction in CKD populations (Bikbov et al., 2020); unilateral ureteral obstruction (UUO) mouse models to investigate renal BDNF expression and pathology; and (Van Sandwijk et al., 2016) single-cell sequencing to detect BDNF expression and regulation. Here, BDNF is linked to chronic kidney disease.