To assess the interaction between antigen-specific CD4+ T cells and macrophages and examine strain- and model-specific differences, we established a DTH model, a T cell-dependent allergic reaction induced by a protein antigen, to evaluate memory T cells derived from transferred antigen-specific CD4+ T cells in the healed skin of C57BL/6 mice (Figure 5G). The gene discussed is CD4; the disease is allergic disease.