HLA-DRB1 and infection: The specific alleles HLA-DRB1*1501 and HLA-DRB1*1503, which confer the greatest predisposition to MS, have also been linked to an increased incidence of infections suspected to have a fungal etiology, such as pulmonary sarcoidosis, uveitis, or allergic bronchopulmonary aspergillosis (16).