IL1A and neoplasm: IL-1α and IL-1β were found to promote epithelial-to-mesenchymal transition (EMT), invasion, and an immunosuppressive microenvironment through recruitment of Myeloid-derived suppressor cells (MDSCs) and tumor associated macrophages (TAMs), while IL-6 and IL-8 were associated with chronic inflammation, cellular proliferation, and tumor progression (49–51).