MEF2C and epilepsy: Its protective mechanisms involve three primary pathways: (1) miR-203/MEF2C/NF-κB Axis: Myocyte enhancer factor 2c (MEF2C), a MADS/MEF2 family transcription factor critical for epilepsy regulation, modulates both neuronal excitability/synaptic plasticity and neuroinflammatory processes via inflammatory mediators and signaling networks (Xu et al., 2015).