AKT1 and epilepsy: (2) In epilepsy models, inhibition of miR-200c-3p expression exerts neuroprotective effects through a triple protective mechanism: (i) activation of the RECK/AKT signaling axis, up-regulation of the expression of cysteine-rich RECK proteins (inhibitors of matrix metalloproteinases), inhibition of the AKT phosphorylation cascade, and attenuate hippocampal neuronal damage (Alexius-Lindgren et al., 2014).