Further support for the alternative start model comes not only from the fact that the Met22 context matches the known ‘GnnAUGG’ mammalian ribosome-binding motif23, but that the enrichment for truncating mutations that can be observed for somatic mutations in tumor samples is nearly absent in the first 21 amino acid positions of STK11 (Supplementary Fig. 4). Here, STK11 is linked to neoplasm.