P2RY12 and psychiatric disorder: Interestingly, we found that 10Hz flicker mitigated stress-induced changes in transcription of microglial receptors P2ry12 and stress associated receptors such as Nr3c1 and Tlr4, as well as microglial Igfbp2, a key gene implicated in affective and psychiatric disorders (Figure 6A, Supplemental Table 3).