To extend these findings to HD patient-derived cells, we examined lymphoblastoid cell lines (LCLs) harboring only the LIG1 rs145821638 (GRCh38 - Chr19:48117686) reference C-allele (LIG1+/+) or heterozygous HD LCLs harboring the 19AM3 modifier variant A-allele (LIG1K845N/+). Here, LIG1 is linked to Huntington disease.