Our data support this conclusion, as all NK-sufficient PEP-R619W mice, including immune-competent (Fig. 1E), Rag1−/− (Fig. 2E), and α-Iso (Fig. 6B) mice, had significantly reduced liver viral titers at days 3 and 5 post-infection compared to PEP-WT counterpart mice. Here, RAG1 is linked to infection.