Carroll et al.83 have shown that in neuropsychiatric systemic lupus erythematosus, an autoimmune disease that often causes cognitive impairments, microglial LAIR1 has been shown to be essential for dampening complement-driven synaptic loss, and down-regulation of microglial Lair1 aggravates cognitive impairment. This evidence concerns the gene LAIR1 and Cognitive impairment.