CSF1R and Alzheimer disease: To study how CSF1R-sensitive microglia impact neuropathology and neural activity in AD, we subjected 11-month-old 5xFAD mice, one of the most commonly used amyloidosis mouse models of AD21, to a diet containing the CSF1R inhibitor PLX3397 for 50 days and performed immunohistochemical (IHC) analysis and electrophysiological recordings.